Table 5.1 (continued)

Strategy

Drug

Cellular target

Original indication

Repositioned indication

Reference

Topiramate

• Gamma-

aminobutyric acid

receptor subunit α-1

• Voltage-gated

sodium channel

α-subunit

• Carbonic anhydrase

Partial-onset seizures, primary

generalized tonic-clonic

seizure epilepsy

Mood disorders, migraine,

weight management

Arnone (2005), Wenzel et al.

(2006), Topiramate (2021)

Mirtazapine

•

5-Hydroxytryptamine

receptor 2A

• 5HT3 serotonin

receptor

• α-2A adrenergic

receptor

• Histamine H1

receptor

Major depressive disorder

Reverse weight loss, improve

sleep

San and Arranz (2006), Maletic

et al. (2017), Mirtazapine (2021)

54

I. A. Farouk et al.